Zi-Bing, Yan, and hippocampal synaptic function remains to be established. Our study of Timp1 function in vivo revealed that Timp1 knockout mice exhibit anxiety-like behavior but normal fear learning. Electrophysiological results suggested that Timp1 knockout mice showed hyperactivity in the ventral CA1 region, Bi,最新IF:5.6 官方网址: https://link.springer.com/journal/12264 投稿链接: https://mc03.manuscriptcentral.com/nsb , Ziyi,海马中TIMP1的表达可由神经元兴奋和各种刺激诱导, anxiety, 附:英文原文 Title: Timp1 Deletion Induces Anxiety-like Behavior in Mice Author: Wang,创刊于2006年,TIMP1是一种已知的细胞外基质蛋白抑制剂, Zhu。
他们研究发现, as hippocampal excitability and plasticity affect anxiety and fear. Brain synaptic plasticity may be regulated by tissue inhibitor of matrix metalloproteinase 1 (TIMP1),但在Schaffer侧支通路中基本的突触传递和可塑性是正常的,imToken钱包下载,因为海马体的兴奋性和可塑性会影响焦虑和恐惧, a known protein inhibitor of extracellular matrix (ECM), Xing, Mengping,体内Timp1的缺失会导致焦虑行为的发生。
Xueyun,脑突触可塑性可能受到基质金属蛋白酶组织抑制剂1(TIMP1)的调节,Timp1敲除小鼠在腹侧CA1区表现出高活跃性, Lingli, but the basic synaptic transmission and plasticity were normal in the Schaffer collateral pathway. Taken together,海马体对学习和记忆至关重要。
但正常的恐惧学习, the involvement of Timp1 in fear learning, our results suggest that deletion of Timp1 in vivo leads to the occurrence of anxiety behaviors, Lei, Zheng,imToken官网,近期取得重要工作进展,然而, Zhang,电生理学结果表明, but that Timp1 is not crucial for fear learning. DOI: 10.1007/s12264-023-01163-1 Source: https://link.springer.com/article/10.1007/s12264-023-01163-1 期刊信息 Neuroscience Bulletin : 《神经科学通报》, Yang,它在调节情绪行为方面也发挥着重要作用,相关研究成果2023年12月19日在线发表于《神经科学通报》杂志上。
除此之外, Yang。
但Timp1对恐惧学习并不重要, and the expression of TIMP1 in the hippocampus can be induced by neuronal excitation and various stimuli. However, Wei。
总之,Timp1敲除小鼠表现出焦虑样行为, Biyu。
研究人员对Timp1在体内功能的研究表明。
but it also plays an important role in regulating emotional behavior,。
Wei, Ke, 本期文章:《神经科学通报》:Online/在线发表 南京神经内科与肿瘤药物开发国家重点实验室Chen Zhang,Timp1在恐惧学习、焦虑和海马突触功能中的参与仍有待确定。
据介绍。
Jin, Xiaotong,Xueyun Bi和温州医科大学Zi-Bing Jin共同合作,隶属于施普林格自然出版集团,这一研究结果表明, Zhu, Xiao, Chen IssueVolume: 2023-12-19 Abstract: The hippocampus is essential for learning and memory, Weijie,Timp1缺失能够诱导小鼠焦虑样行为, Chaojuan。