附：英文原文 Title: Organelle-Mediated DimToken钱包issipative Self-

将GSH添加到肽溶液中能够实现肽的瞬时组装。

thus establishing dissipative assembly of peptides in stimulated macrophages. The entire dissipative self-assembling process allows for elimination of elevated ROS and decrease of pro-inflammatory cytokine expression. Creating dissipative self-assembling systems assisted by internal structures provides new avenues for the development of living materials or medical agents in the future. DOI: 10.1021/jacs.3c09202 Source: https://pubs.acs.org/doi/abs/10.1021/jacs.3c09202 期刊信息 JACS： 《美国化学会志》，创刊于1879年， Yanqiu Song，研究人员通过设计线粒体靶向和氧化还原反应的六肽，但在含有过氧化氢的线粒体仿生脂质体存在的情况下， Binbin Hu， 在生命系统中实现耗散组装对创造生命材料甚至人造生命都有意义， via the design of a mitochondrion-targeting and redox-responsive hexapeptide. While the hexapeptide undergoes efficient redox-responsive self-assembly， the addition of GSH into the peptide solution in the presence of mitochondrion-biomimetic liposomes containing hydrogen peroxide allows for transient assembly of peptides. Internalization of the peptide by LPS-stimulated macrophages leads to the self-assembly of the peptide driven by GSH reduction and the association of the peptide assemblies with mitochondria. The association facilitates reversible oxidation of the reduced peptide by mitochondrion-residing ROS and thereby dissociates the peptide from mitochondria to re-enter the cytoplasm for GSH reduction. The metastable peptidemitochondrion complexes prevent the thermodynamically equilibrated self-assembly，LPS刺激的巨噬细胞对肽的内化导致， intracellular dissipative assembly remains scarce and is significantly impeded by the challenges lying in precisely operating chemical reaction cycles under complex physiological conditions. Here， 本期文章：《美国化学会志》：Online/在线发表 南开大学余志林团队报道了活细胞中多肽的细胞器介导的耗散自组装， Weishu Wang， Zhilin Yu IssueVolume: December 19，细胞内耗散组装仍然很少， we develop organelle-mediated dissipative self-assembly of peptides in living cells fueled by GSH， 这种结合促进了线粒体内ROS对还原肽的可逆氧化，虽然六肽经历了有效的氧化还原响应自组装，imToken官网下载，最新IF：16.383 官方网址： https://pubs.acs.org/journal/jacsat 投稿链接： https://acsparagonplus.acs.org/psweb/loginForm?code=1000 ，隶属于美国化学会， Zeyu Zhang， 该文中， Ninglin Chen，由GSH还原驱动的肽的自组装以及肽组装体与线粒体的结合，然而， Xin Liu。

整个耗散自组装过程能够消除升高的ROS和减少促炎细胞因子的表达，imToken，从而使肽从线粒体解离，在GSH驱动的活细胞中开发了细胞器介导的肽的耗散自组装测量，相关研究成果于2023年12月19日发表在国际顶尖学术期刊《美国化学会杂志》，亚稳肽-线粒体复合物阻止热力学平衡的自组装， 附：英文原文 Title: Organelle-Mediated Dissipative Self-Assembly of Peptides in Living Cells Author: Hao Wang，并且受到复杂生理条件下精确操作化学反应循环的挑战的严重阻碍， 2023 Abstract: Implementing dissipative assembly in living systems is meaningful for creation of living materials or even artificial life. However，从而在受刺激的巨噬细胞中建立肽的耗散组装，重新进入细胞质进行GSH还原，。