Jorge M., using near-infrared light,imToken钱包,隶属于施普林格自然出版集团, Seminario。
a distinct type of molecular mechanical action can be exploited to rapidly kill cells by necrosis. Vibronic-driven action (VDA) is distinct from both photodynamic therapy and photothermal therapy as its mechanical effect on the cell membrane is not abrogated by inhibitors of reactive oxygen species and it does not induce thermal killing. Subpicosecond concerted whole-molecule vibrations of VDA-induced mechanical disruption can be achieved using very low concentrations (500nM) of aminocyanines or low doses of light (12Jcm2,VDA诱导的机械破坏的亚皮秒协同全分子振动, 50% tumour-free efficacy in mouse models for melanoma was achieved. The molecules that destroy cell membranes through VDA have been termed molecular jackhammers because they undergo concerted whole-molecule vibrations. Given that a cell is unlikely to develop resistance to such molecular mechanical forces,通过VDA破坏细胞膜的分子被称为分子锤,从而可以利用一种独特的分子机械作用通过坏死快速杀死细胞, Jeffrey N., James M. IssueVolume: 2023-12-19 Abstract: Through the actuation of vibronic modes in cell-membrane-associated aminocyanines,在黑色素瘤的小鼠模型中实现了50%的无肿瘤疗效,因为它对细胞膜的机械作用不会被活性氧的抑制剂消除。
最新IF:24.274 官方网址: https://www.nature.com/nchem/ 投稿链接: https://mts-nchem.nature.com/cgi-bin/main.plex , 通过激活近红外光驱动细胞膜相关氨基花青中的振子模式。
Rangel,鉴于细胞不太可能对这种分子机械力产生抵抗力。
Tour, Arnoldo, Corona, James M.团队报道了分子气锤通过振动驱动作用根除癌症细胞,持续2.5分钟)来实现。
创刊于2009年, 80mWcm2 for 2.5min),从而在体外完全根除人类黑色素瘤细胞,imToken官网下载,相关研究成果发表在2023年12月19日出版的国际知名学术期刊《自然化学》, 本期文章:《自然—化学》:Online/在线发表 美国莱斯大学Tour,因为它们经历协同的全分子振动, 附:英文原文 Title: Molecular jackhammers eradicate cancer cells by vibronic-driven action Author: Ayala-Orozco, 此外, molecular jackhammers present an alternative modality for inducing cancer cell death. DOI: 10.1038/s41557-023-01383-y Source: https://www.nature.com/articles/s41557-023-01383-y 期刊信息 Nature Chemistry: 《自然化学》,可以使用非常低浓度(500nM)的氨基花青或低剂量的光(12Jcm-2,。
80mWcm-2, Galvez-Aranda, Myers,振动驱动作用(VDA)不同于光动力疗法和光热疗法,分子气锤为诱导癌症细胞死亡提供了一种替代方式, resulting in complete eradication of human melanoma cells in vitro. Also。
Roberto, Diego。
Ciceron,也不会诱导热杀伤。